1442-06-4

Basic information

• Product Name: 4-(METHYLTHIO)BENZOYL CHLORIDE 95
• Synonyms: 4-(METHYLTHIO)BENZOYL CHLORIDE 95;4-(Methylthio)benzoic acid chloride;4-methylsulfanylbenzoyl chloride;4-(Methylthio)benzoyl chloride 95%
• CAS NO: 1442-06-4
• Molecular Formula: C₈H₇ClOS
• Molecular Weight: 186.66
• EINECS: 215-882-4
• Product Categories: Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 1442-06-4.mol
• Article Data: 29

Chemical Properties

• Melting Point: 52-56 °C(lit.)
• Boiling Point: 278.6°Cat760mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 0.00422mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(1442-06-4)
• EPA Substance Registry System: 4-(METHYLTHIO)BENZOYL CHLORIDE 95(1442-06-4)

Safety Data

• Hazard Codes: C
• Statements: 34-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 1442-06-4(Hazardous Substances Data)

Usage

General Description

4-(Methylthio)benzoyl chloride 95 is a chemical compound that is commonly used as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. It is a benzoyl chloride derivative with a methylthio (methyl sulfide) group attached to the benzene ring. 4-(METHYLTHIO)BENZOYL CHLORIDE 95 is known for its reactivity as a versatile acylating agent, and it is often employed in the production of pharmaceuticals, dyes, and other fine chemicals. It is also used as a building block in organic synthesis and is valued for its ability to introduce the benzoyl moiety to other organic compounds, making it an important intermediate in the manufacturing of a wide range of chemical products.

InChI:InChI=1/C8H7ClOS/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3

Upstream product

• 13205-48-6 4-(methylthio)benzoic acid 
• 35371-03-0 4-iodothioanisole 
• 141-75-3 butyryl chloride 
• 100-20-9 terephthaloyl chloride 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 90005-49-5 4-(methylthio)benzamide 
• 83167-15-1 1,3-dihydro-4-ethyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one 
• 1257513-87-3 5-hydroxy-4'-methylthioflavone 
• 1357168-60-5 N-[3-(2,5-dimethylbenzyloxy)-4-(N-methanesulfonyl-N-methylamino)phenyl]-4-methylsulfanylbenzamide 
• 1421616-82-1 N-benzyl-4-(methylthio)benzamide 
• 3795-79-7 methyl 4-(methylthio)benzoate 
• 791806-41-2 3-(4,4-diethoxy-tetrahydro-pyran-3-yloxy)-4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrazole 
• 329076-08-6 3-(4-fluorophenacyloxy)-4-(4-fluorophenyl)-5-(4-methanesulfonylphenyl)pyrazole 

Relevant articles and documents

Direct Synthesis of Enamides via Electrophilic Activation of Amides

A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.

ONIUM SALT, COMPOSITION, AND DEVICE MANUFACTURING METHOD USING THE SAME

PROBLEM TO BE SOLVED: To provide a photoacid generator for a chemically amplified resist simultaneously satisfying characteristics of sensitivity, resolution and pattern performance. SOLUTION: An onium salt is represented by one selected from general formulas (1) and (2). (R11 and R12 are each an alkyl group, alkenyl group, aryl group, or the like; R13 and R14 are each an alkyl group, hydroxy group, alkoxy group, or the like; R15 and R16 are each an alkyl group, alkenyl group, aryl group, or the like; L1 is a direct bond, alkylene group, alkenylene group, arylene group, or the like; L4 and L5 are each a direct bond, alkenylene group, alkynylene group, or carbonyl group; Y is an oxygen or sulfur atom; h and i are each an integer from 1 to 3; j is an integer from 0 to 4 if h is 1, from 0 to 6 if h is 2, and from 0 to 8 if h is 3; k is an integer from 0 to 5 if i is 1, from 0 to 7 if i is 2, and from 0 to 9 if i is 3; X- represents a monovalent counter anion; and R17 is an aryl group or heteroaryl group.) SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Preparation method of aromatic acyl chloride

The invention discloses a preparation method of aromatic acyl chloride. An aromatic acyl chloride compound is prepared through a reaction of aryl carboxylic acid and phosphorus trichloride. The preparation method of the aromatic acyl chloride has the advantages that the phosphorus trichloride is taken as a chloride reagent, the corresponding acyl chloride is synthesized from the aryl carboxylic acid, so that the production cost is low, the operation is simple, a by-product is low in toxicity, the environmental friendliness is achieved, the yield is high, and the method is conductive to industrial production.