methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

Base Information

Chemical Name:methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate
CAS No.:1606977-18-7
Molecular Formula:C₂₁H₁₉ClN₂O₃
Molecular Weight:382.846
Hs Code.:

Synonyms:methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

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Chemical Property of methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

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Technology Process of methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

There total 4 articles about methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1153411-67-6
4-chloro-2-(3-chlorophenyl)-6-ethyl pyrimidine

: 1606977-18-7
methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 7h;

Reference yield:

: 24095-60-1
3-chlorobenzenecarboximidamide hydrochloride

: 1606977-18-7
methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 20 h / Reflux

2: trichlorophosphate / 5 h / 0 - 100 °C

3: potassium carbonate / acetonitrile / 7 h / 85 °C

With sodium methylate; potassium carbonate; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1021/acs.jmedchem.9b00193

Reference yield:

: 4949-44-4
ethyl propanoylacetate

: 1606977-18-7
methyl 2-(4-((2-(3-chlorophenyl)-6-ethylpyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 20 h / Reflux

2: trichlorophosphate / 5 h / 0 - 100 °C

3: potassium carbonate / acetonitrile / 7 h / 85 °C

With sodium methylate; potassium carbonate; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.1021/acs.jmedchem.9b00193