4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

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Chemical Name:4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate
CAS No.:1365803-17-3
Molecular Formula:CH₂O₂*C₂₉H₂₅F₆N₅O₂
Molecular Weight:635.566
Hs Code.:

Synonyms:4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

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Chemical Property of 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

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Technology Process of 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

There total 5 articles about 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1365802-70-5
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

: 1365803-17-3
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 3h;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1365803-17-3
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3.1: sodium hydroxide; water / methanol / 2 h / Reflux

3.2: Acidic aqueous solution

4.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 3 h / 20 °C

With potassium phosphate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ISOPROPYLAMIDE; water; mineral oil;

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 1365803-17-3
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)-N-(2-morpholin-4-ylethyl)benzamide formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3.1: sodium hydroxide; water / methanol / 2 h / Reflux

3.2: Acidic aqueous solution

4.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 3 h / 20 °C

With potassium phosphate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ISOPROPYLAMIDE; water; mineral oil;