4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

Base Information

Chemical Name:4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid
CAS No.:1365802-70-5
Molecular Formula:C₂₃H₁₃F₆N₃O₂
Molecular Weight:477.366
Hs Code.:

Synonyms:4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

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Chemical Property of 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

Chemical Property:

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Technology Process of 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

There total 4 articles about 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1365802-95-4
methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate

: 1365802-70-5
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

Guidance literature:: methyl 4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoate; With water; sodium hydroxide; In methanol; for 2h; Reflux;

Acidic aqueous solution;

Reference yield:

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1365802-70-5
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3.1: sodium hydroxide; water / methanol / 2 h / Reflux

3.2: Acidic aqueous solution

With potassium phosphate; water; sodium hydride; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water; mineral oil;

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 1365802-70-5
4-(4-{[3,5-bis(trifluoromethyl)phenyl]amino}phthalazin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 60 °C

2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

3.1: sodium hydroxide; water / methanol / 2 h / Reflux

3.2: Acidic aqueous solution

With potassium phosphate; water; sodium hydride; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water; mineral oil;