2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester

Base Information

• Chemical Name: 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester
• CAS No.: 212769-00-1
• Molecular Formula: C₂₇H₃₉NO₆S
• Molecular Weight: 505.676

Synonyms:2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester

Chemical Property of 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester

There total 5 articles about 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-methoxy-benzenesulfonyl)-propionic acid ethyl ester (212768-83-7) + 4-(2-N,N-diisopropyl amino-ethoxy)-benzyl chloride → 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester (212769-00-1)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; Heating;

DOI:10.1021/jm0205548

Reference yield:

4-Methoxybenzenethiol (696-63-9) → 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester (212769-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / acetone / 8 h / Heating

2: 95 percent / aq. Oxone / methanol; tetrahydrofuran / 4 h / 20 °C

3: 88 percent / 18-crown-6; K₂CO₃ / acetone / Heating

With Oxone; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1021/jm0205548

Reference yield:

Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid ethyl ester (212769-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / acetone / 8 h / Heating

2: 95 percent / aq. Oxone / methanol; tetrahydrofuran / 4 h / 20 °C

3: 88 percent / 18-crown-6; K₂CO₃ / acetone / Heating

With Oxone; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1021/jm0205548

upstream raw materials:

2-(4-methoxy-benzenesulfonyl)-propionic acid ethyl ester

4-Methoxybenzenethiol

Ethyl 2-bromopropionate

2-(4-methoxy-phenylsulfanyl)-propionic acid ethyl ester

Downstream raw materials:

2-(4-methoxy-benzenesulfonyl)-2-methyl-3-[4-(2-N,N-diisopropyl amino-ethoxy)-phenyl]-propionic acid

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