(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

Base Information

Chemical Name:(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine
CAS No.:884512-33-8
Molecular Formula:C₂₄H₂₈FNO₄
Molecular Weight:413.489
Hs Code.:

Synonyms:(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

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Chemical Property of (3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

Chemical Property:

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Technology Process of (3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

There total 2 articles about (3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 884510-86-5
(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 884512-33-8
(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

Guidance literature:: 2-fluoro-(2-tolyloxy)benzene; With n-butyllithium; In tetrahydrofuran; at -70 ℃;

(R)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate; In tetrahydrofuran; at 20 ℃; for 12h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 884512-33-8
(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -70 °C

2.2: 12 h / 20 °C

2.3: 0 °C

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield: 30.0%

: 884512-33-8
(3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine

: 634590-61-7
(4-methoxybutyl)magnesium chloride

: 884512-35-0
(R)-tert-butyl 3-((S)-1-(3-(o-tolyloxy)-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)piperidine-1-carboxylate

Guidance literature:: (3R)-1-tert-butoxycarbonyl-3-(2-fluoro-3-(o-tolyloxy)benzoyl)piperidine; (4-methoxybutyl)magnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃;