4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Base Information

Chemical Name:4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester
CAS No.:1350552-02-1
Molecular Formula:C₄₃H₄₂FN₉O₉
Molecular Weight:847.86
Hs Code.:

4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Synonyms:4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

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Chemical Property of 4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

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Technology Process of 4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

There total 6 articles about 4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1350552-01-0
3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

: 1350552-02-1
4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: pyridine-4-carboxylic acid; With triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In dichloromethane; for 1h; Inert atmosphere;

3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester; dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 959-22-8
p-nitrophenylbenzoate

: 1350552-02-1
4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 50 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / dichloromethane / 1 h / Inert atmosphere

3.2: 20 °C

With caesium carbonate; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 951803-95-5
4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate

: 1350552-02-1
4-pyridinecarboxylic acid 2-(3-{(4-{amino[benzoylimino]methyl}phenylamino)-[5-(3-methoxy-2,2-dimethylpropionyloxymethoxy)-1-pyrimidin-2-yl-1H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 50 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate / dichloromethane / 1 h / Inert atmosphere

3.2: 20 °C

With caesium carbonate; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;