3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

Base Information

Chemical Name:3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester
CAS No.:1350552-01-0
Molecular Formula:C₃₇H₃₉FN₈O₈
Molecular Weight:742.764
Hs Code.:

3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

Synonyms:3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

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Chemical Property of 3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

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Technology Process of 3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

There total 4 articles about 3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350552-00-9
3-methoxy-2,2-dimethylpropionic acid chloromethyl ester

: 1350551-90-4
N-[1-amino-1-(4-{[[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl]amino}phenyl)methylidene]benzamide

: 1350552-01-0
3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

Reference yield:

: 959-22-8
p-nitrophenylbenzoate

: 1350552-01-0
3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 50 °C

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With caesium carbonate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 951803-95-5
4-({[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]triazol-3-yl)methyl}amino)benzamidine acetate

: 1350552-01-0
3-methoxy-2,2-dimethylpropionic acid 5-{[4-(amino[benzoylimino]methyl)phenylamino]-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 50 °C

2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With caesium carbonate; triethylamine; In N,N-dimethyl-formamide;