N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid

Base Information

• Chemical Name: N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid
• CAS No.: 164794-97-2
• Molecular Formula: C₃₃H₅₄N₄O₈
• Molecular Weight: 634.814
• Mol file: 164794-97-2.mol

Synonyms:N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid

Chemical Property of N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid

There total 2 articles about N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-[(1,4,8,11-tetraazacyclotetradec-1-yl)methyl]benzoic acid (107265-48-5) → N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid (164794-97-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 ℃;

DOI:10.1021/jm00015a001

Reference yield:

C34H56N4O8 (321747-01-7) → N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid (164794-97-2)

Guidance literature:

C₃₄H₅₆N₄O₈; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

With citric acid; In water; at 0 ℃; pH=4;

Reference yield:

BRI7082 (321913-14-8) + N-Boc protected 4-<(1,4,8,11-tetraazacyclotetradec-1-yl)methyl>benzoic acid (164794-97-2) → C66H99N9O13 (321747-02-8)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

di-tert-butyl dicarbonate

4-[(1,4,8,11-tetraazacyclotetradec-1-yl)methyl]benzoic acid

C₃₄H₅₆N₄O₈

Downstream raw materials:

C₆₆H₉₉N₉O₁₃