{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

Base Information

Chemical Name:{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone
CAS No.:321378-35-2
Molecular Formula:C₂₁H₁₇ClN₂O₃
Molecular Weight:380.831
Hs Code.:

Synonyms:{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

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Chemical Property of {2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

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Technology Process of {2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

There total 5 articles about {2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 210966-95-3
[2-chloro-4-(2-nitro-phenylamino)-phenyl]-o-tolyl-methanone

: 74-88-4
methyl iodide

: 321378-35-2
{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: [2-chloro-4-(2-nitro-phenylamino)-phenyl]-o-tolyl-methanone; With sodium hydride; In tetrahydrofuran; for 0.25h;

methyl iodide; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jm030851s

Reference yield:

: 99-60-5
2-chloro-4-nitrobenzoic acid

: 321378-35-2
{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: SOCl₂ / toluene; dimethylformamide / 2 h / Heating

2.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

2.2: ZnCl₂ / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2.3: 76 percent / Pd(PPh₃)4 / tetrahydrofuran; hexane / 0 - 20 °C

3.1: 96 percent / SnCl₂*2H₂O / ethanol / 2 h / 70 °C

4.1: 69 percent / KOtBu / dimethylsulfoxide / 18 h / 20 °C

5.1: NaH / tetrahydrofuran / 0.25 h

5.2: 100 percent / tetrahydrofuran / 2 h / Heating

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium hydride; tin(ll) chloride; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm030851s

Reference yield:

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 321378-35-2
{2-chloro-4-[methyl(2-nitrophenyl)amino]phenyl}(2-methylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

1.3: 76 percent / Pd(PPh₃)4 / tetrahydrofuran; hexane / 0 - 20 °C

2.1: 96 percent / SnCl₂*2H₂O / ethanol / 2 h / 70 °C

3.1: 69 percent / KOtBu / dimethylsulfoxide / 18 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.25 h

4.2: 100 percent / tetrahydrofuran / 2 h / Heating

With n-butyllithium; potassium tert-butylate; sodium hydride; tin(ll) chloride; In tetrahydrofuran; ethanol; hexane; dimethyl sulfoxide;
DOI:10.1021/jm030851s