N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Base Information

Chemical Name:N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester
CAS No.:88130-47-6
Molecular Formula:C₂₉H₃₇N₇O₇
Molecular Weight:595.655
Hs Code.:

N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N<sup>ω</sup>-nitro-L-arginine methyl ester

Synonyms:N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Chemical Property:

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Technology Process of N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

There total 6 articles about N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 51298-62-5
nitro-L-arginine methyl ester hydrochloride

: 88084-13-3
N-benzoyl-L-prolyl-DL-α-methylphenylalanine

: 88130-47-6
N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Guidance literature:: With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25 ℃; for 72h; pH 7.0-7.5;
DOI:10.1021/jm00369a017

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 88130-47-6
N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 3 h / 25 °C

2: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: DCC / tetrahydrofuran / 1.5 h

4: tetrahydrofuran / 72 h / 25 °C

5: 98 percent / 2.5 N NaOH / methanol / 25 °C

6: 29 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With pyridine; N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00369a017

Reference yield:

: 98-88-4
benzoyl chloride

: 88130-47-6
N-benzoyl-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 3 h / 25 °C

2: H₂ / 10percent Pd/C / ethanol / 3102.9 Torr

3: DCC / tetrahydrofuran / 1.5 h

4: tetrahydrofuran / 72 h / 25 °C

5: 98 percent / 2.5 N NaOH / methanol / 25 °C

6: 29 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With pyridine; N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm00369a017