N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide
CAS No.:1195768-17-2
Molecular Formula:C₂₂H₁₇ClF₂N₄O₂S₂
Molecular Weight:506.984
Hs Code.:

Synonyms:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Chemical Property of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

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Technology Process of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

There total 9 articles about N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1195768-16-1
{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}amine

: 60230-36-6
2,6-difluorobenzene-1-sulfonyl chloride

: 1195768-17-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1195768-17-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane

2: lithium hexamethyldisilazane

3: N-Bromosuccinimide / N,N-dimethyl-formamide

With pyridine; N-Bromosuccinimide; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021

Reference yield:

: 1244641-87-9
N-{3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}-2,6-difluorobenzenesulfonamide

: 1195768-17-2
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide

With N-Bromosuccinimide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021