3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Base Information

Chemical Name:3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate
CAS No.:1472067-95-0
Molecular Formula:C₁₆H₁₃BrN₆O₃S
Molecular Weight:449.288
Hs Code.:

Synonyms:3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

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Chemical Property of 3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

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Technology Process of 3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

There total 4 articles about 3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1472068-06-6
4-[(2-bromo-4-hydroxybenzyl)(4H-1,2,4-triazol-4-yl)amino]benzonitrile

: 1472067-95-0
3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: With sulphamoyl chloride; In N,N-dimethyl acetamide; at 0 - 20 ℃;
DOI:10.1002/cmdc.201300015

Reference yield:

: 60710-39-6
3-bromo-p-cresol

: 1472067-95-0
3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 1 h / 20 °C

2.1: N-Bromosuccinimide; benzoic acid / tetrachloromethane / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

3.2: 48 h

4.1: potassium hydroxide / methanol / 2 h

5.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With pyridine; N-Bromosuccinimide; sulphamoyl chloride; sodium hydride; benzoic acid; potassium hydroxide; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015

Reference yield:

: 1472068-07-7
3-bromo-4-(bromomethyl)phenyl benzoate

: 1472067-95-0
3-bromo-4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

1.2: 48 h

2.1: potassium hydroxide / methanol / 2 h

3.1: sulphamoyl chloride / N,N-dimethyl acetamide / 0 - 20 °C

With sulphamoyl chloride; sodium hydride; potassium hydroxide; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300015