60710-39-6

Basic information

• Product Name: 3-BROMO-4-METHYLPHENOL
• Synonyms: 3-BROMO-4-METHYLPHENOL;2-Bromo-4-hydroxytoluene, 3-Bromo-p-cresol;2-Bromo-4-hydroxytoluene;Phenol,3-bromo-4-methyl-
• CAS NO: 60710-39-6
• Molecular Formula: C₇H₇BrO
• Molecular Weight: 187.03
• Mol File: 60710-39-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 54-57°C
• Boiling Point: 244.6±20.0℃ (760 Torr)
• Flash Point: 101.7±21.8℃
• Appearance: /
• Density: 1.554±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0193mmHg at 25°C
• Refractive Index: 1.5772 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 9.30±0.18(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3-BROMO-4-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-METHYLPHENOL(60710-39-6)
• EPA Substance Registry System: 3-BROMO-4-METHYLPHENOL(60710-39-6)

Safety Data

• Hazardous Substances Data: 60710-39-6(Hazardous Substances Data)

Usage

Chemical Properties

off-white crystalline

Uses

Different sources of media describe the Uses of 60710-39-6 differently. You can refer to the following data:
1. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
2. 3-Bromo-4-methylphenol is a component of the marine alga polysophornia Sphaerocarpa. It is also a useful raw material for organic synthesis and pharmaceuticals.

InChI:InChI=1/C7H7BrO/c1-5-2-3-6(9)4-7(5)8/h2-4,9H,1H3

Upstream product

• 7745-91-7 3-bromo-4-methylaniline 
• 6627-55-0 2-bromo-p-cresol 
• 7446-70-0 aluminium trichloride 
• 108-86-1 bromobenzene 
• 106-44-5 p-cresol 
• 106-41-2 4-bromo-phenol 
• 39953-10-1 2,4,6-tribromo-4-methylcyclohexa-2,5-dienone 
• 2758-18-1 3-Methyl-2-cyclopenten-1-one 
• 75-25-2 Bromoform 
• 95-46-5 2-methylphenyl bromide 
• 2432-14-6 3,5-dibromo-4-hydroxytoluene 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 36776-51-9 2,3,6-tribromo-4-methyl-phenol 

Downstream Products

• 36942-56-0 3-bromo-4-methylanisole 
• 3698-65-5 O-(α,α'-Dichlorisopropyl)-O-(3-brom-4-methylphenyl)-schwefligsaeureester 
• 106-44-5 p-cresol 
• 6627-55-0 2-bromo-p-cresol 
• 19936-51-7 4-(2-Methyl-5-methoxy-phenyl)-buttersaeure 
• 19936-50-6 4-<2-Methyl-5-methoxy-phenyl>-4-oxo-buttersaeure 
• 1373403-28-1 C₁₉H₃₃BO₃Si 
• 1373403-19-0 C₂₄H₂₀BrNO₄ 
• 164513-48-8 (3-bromo-4-methyl-phenoxy)-tert-butyl-dimethyl-silane 

Relevant articles and documents

Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring Opening

Disrotatory – thermally allowed – 2π-electrocyclic ring-opening reactions require high temperatures to proceed. Herein, we report the first anion-accelerated 2π-electrocyclic ring opening of 6,6-dihalobicyclo[3.1.0]hexan-2-ones at low temperature to give the corresponding meta-halophenols in good to high yields (18 examples, 29–92 % yield, average: 65 %). Many of the phenols have unconventional substitution patterns and are reported here for the first time. Furthermore, the strength of the methodology was shown by the total synthesis of the densely functionalized phenolic natural product caramboxin (isolated as the lactam dehydrate). The reaction mechanism underlying the anion-acceleration was investigated in an ab initio study, which concluded that base-mediated proton abstraction anti to the concurrently departing endo-bromine was the initiating step in an overall concerted reaction mechanism leading directly to the meta-halophenol.

Magnolol dimer-derived fragments as PPARγ-selective probes

Partial agonists of the transcription factor PPARγ (peroxisome proliferator-activated receptor γ) have shown potential for the treatment of metabolic and inflammatory conditions and novel activators serve as valuable tool and lead compounds. Based on the

Explorations of the solubilizing effectiveness of CH3OCH2CH2O substituents in the photocyclizations of some 1,2-diarylethylenes to [n]phenacenes

We have previously published many photocyclizations of 1,2-diarylethylenes to produce zig-zag aromatic ring systems with n = 5, 7, and 11 fused benzene rings. We invented the name [n]phenacenes for these compounds. To increase their solubilities we attach