(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

Base Information

Chemical Name:(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one
CAS No.:863638-84-0
Molecular Formula:C₂₈H₄₂O₅Si
Molecular Weight:486.724
Hs Code.:

Synonyms:(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

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Chemical Property of (4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

Chemical Property:

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Technology Process of (4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

There total 6 articles about (4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863638-83-9
(3S)-5-benzyloxy-3-(benzyloxy-diisopropyl-silanyloxy)-pentanal

: 127184-17-2
C₂₃H₃₉BO

: 863638-84-0
(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

Guidance literature:: (3S)-5-benzyloxy-3-(benzyloxy-diisopropyl-silanyloxy)-pentanal; C₂₃H₃₉BO; In diethyl ether; at -78 - -20 ℃; for 21h;

With dihydrogen peroxide; In methanol; at 20 ℃; for 2h; pH=7;
DOI:10.1039/b505746a

Reference yield:

: 863638-78-2
[1-(2-benzyloxy-ethyl)-but-3-enyloxy]-chloro-diisopropyl-silane

: 863638-84-0
(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6.08 g / CH₂Cl₂ / 20 °C

2.1: 77 percent / aq. OsO₄; NMO / acetone; 2-methyl-propan-2-ol / 48 h / 20 °C

3.1: 65 percent / Na₂CO₃; Pb(OAc)4 / CH₂Cl₂ / 0.33 h / 0 °C

4.1: diethyl ether / 21 h / -78 - -20 °C

4.2: 954 mg / aq. H₂O₂ / methanol / 2 h / 20 °C / pH 7

With lead(IV) acetate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium carbonate; In diethyl ether; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1039/b505746a

Reference yield:

: 863638-82-8
(1R)-benzyloxy-[1-(2-benzyloxy-ethyl)-but-3-enyloxy]-diisopropyl-silane

: 863638-84-0
(4S,6S)-8-benzyloxy-6-(benzyloxy-diisopropyl-silanyloxy)-4-hydroxy-octan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / aq. OsO₄; NMO / acetone; 2-methyl-propan-2-ol / 48 h / 20 °C

2.1: 65 percent / Na₂CO₃; Pb(OAc)4 / CH₂Cl₂ / 0.33 h / 0 °C

3.1: diethyl ether / 21 h / -78 - -20 °C

3.2: 954 mg / aq. H₂O₂ / methanol / 2 h / 20 °C / pH 7

With lead(IV) acetate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium carbonate; In diethyl ether; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1039/b505746a