2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

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Chemical Name:2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid
CAS No.:1412403-05-4
Molecular Formula:C₁₅H₁₃N₅O₄
Molecular Weight:327.299
Hs Code.:

Synonyms:2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

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Chemical Property of 2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

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Technology Process of 2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

There total 4 articles about 2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: (R,S)-2-[2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-3-nitropropyl]-1H-isoindole-1,3(2H)-dione

: 1412403-05-4
2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

Guidance literature:: (R,S)-2-[2-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-3-nitropropyl]-1H-isoindole-1,3(2H)-dione; With sodium hydroxide; In water; at 20 ℃; for 0.0833333h; Inert atmosphere;

With sulfuric acid; In water; at -5 - 20 ℃; Inert atmosphere;
DOI:10.1039/c2ob26387d

Reference yield:

: 1412403-03-2
2-[(2E)-3-nitroprop-2-en-1-yl]-1H-isoindole-1,3(2H)-dione

: 1412403-05-4
2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethyl acetate; tetrahydrofuran; water / 3.75 h / 60 °C / Inert atmosphere

2.1: sodium hydroxide / water / 0.08 h / 20 °C / Inert atmosphere

2.2: -5 - 20 °C / Inert atmosphere

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate; 1.1: |Michael Addition;
DOI:10.1039/c2ob26387d

Reference yield:

: 2913-97-5
N-phthalimidyl-2-aminoacetaldehyde

: 1412403-05-4
2-({[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino}carbonyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran; methanol / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic anhydride / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere

2.2: 0.08 h / -10 °C / Inert atmosphere; Alkaline conditions

3.1: ethyl acetate; tetrahydrofuran; water / 3.75 h / 60 °C / Inert atmosphere

4.1: sodium hydroxide / water / 0.08 h / 20 °C / Inert atmosphere

4.2: -5 - 20 °C / Inert atmosphere

With potassium tert-butylate; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; 1.1: |Henry Nitro Aldol Condensation / 3.1: |Michael Addition;
DOI:10.1039/c2ob26387d