2913-97-5

Basic information

• Product Name: N-(2-Oxoethyl)phthalimide
• Synonyms: (1,3-DIOXO-1,3-DIHYDROISOINDOL-2-YL)ACETALDEHYDE;1,3-DIOXO-2-ISOINDOLINEACETALDEHYDE;2-(1,3-DIOXOISOINDOLIN-2-YL)ACETALDEHYDE;2-PHTHALIMIDOACETALDEHYDE;N-(2-OXOETHYL)PHTHALIMIDE;N-(FORMYLMETHYL)PHTHALIMIDE;n-(formylmethyl)-phthalimid;PHTHALIMIDOACETALDEHYDE
• CAS NO: 2913-97-5
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Product Categories: Aromatics Compounds;Aromatics;Cross Linking Reagents;Heterocycles;Miscellaneous Reagents
• Mol File: 2913-97-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 116-118°C
• Boiling Point: 324.319 °C at 760 mmHg
• Flash Point: 151.476 °C
• Appearance: Off-white solid
• Density: 1.376 g/cm³
• Vapor Pressure: 0.000247mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
• PKA: -2.45±0.20(Predicted)
• CAS DataBase Reference: N-(2-Oxoethyl)phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Oxoethyl)phthalimide(2913-97-5)
• EPA Substance Registry System: N-(2-Oxoethyl)phthalimide(2913-97-5)

Safety Data

• RTECS: TI5125000
• HazardClass: IRRITANT
• Hazardous Substances Data: 2913-97-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Phthalimidoacetaldehyde (cas# 2913-97-5) is a compound useful in organic synthesis.

InChI:InChI=1/C10H7NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,6H,5H2

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 74509-96-9 2,5-Dioxo-4-phenyl-6-phthalimido-3-hexancarbonsaeure-ethylester 
• 74509-94-7 1,3-Diphenyl-5-phthalimidopentan-1,4-dion 
• 184688-89-9 2-(2-{[(S)-1-(2-Hydroxy-phenyl)-2-(1H-imidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-isoindole-1,3-dione 
• 74509-93-6 1-Phenyl-5-phthalimidopentan-1,4-dion 
• 258501-34-7 5'-O-(tert-butyldiphenylsilyl)-2'-O-[2-[[N-methyl-N-(2-phthalimidoethyl)amino]oxy]ethyl]-5-methyluridine 
• 4335-61-9 2-[(Z)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 17480-07-8 2-[(E)-3-phenylprop-2-enyl]-2,3-dihydro-1H-isoindole-1,3-dione 
• 1037048-59-1 2-(2-hydroxy-3-methyl-3-phenylpent-4-en-1-yl)isoindoline-1,3-dione 
• 1037048-61-5 2-(3-(4-fluorophenyl)-2-hydroxy-3-methylpent-4-en-1-yl)isoindoline-1,3-dione 
• 1141781-69-2 C₂₃H₂₆N₂O₃ 

Relevant articles and documents

Design, synthesis and structure - Activity relationship of phthalimides endowed with dual antiproliferative and immunomodulatory activities

Twenty-seven compounds showed dual anti-cancer and immunomodulatory activities.Series (6a-f) show perceptual inhibition range of 32.1-96.8 for SF-295 cell line.Compounds (6b) and (6f) show better inhibition profile of cancer cell lines than thl.The functionalization of series 3 to series 6 achieved better anti-cancer profile.

HETEROCYCLIC COMPOUNDS AND USE THEREOF

Heterocyclic compounds of Formula (I) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. Further disclosed are methods of using one of the heterocyclic compounds for mobilizing hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation, and for treating tissue injury, cancer, inflammatory disease, and autoimmune disease.

4,5-DIHYDROISOXAZOLE DERIVATIVES AS NAMPT INHIBITORS

The present invention provides substituted 4,5-dihydroisoxazole derivatives of formula (I), which may be therapeutically useful, more particularly NAMPT inhibitors and in which R1 R2, Y, X, "Het" and "p" have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPT) in a mammal. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted 4,5-dihydroisoxazole derivatives of formula (I) or a pharmaceutically acceptable salts or stereoisomers or N-oxide thereof.