4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

Base Information

Chemical Name:4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide
CAS No.:1573056-21-9
Molecular Formula:C₂₃H₂₂F₃N₅O₄
Molecular Weight:489.454
Hs Code.:

Synonyms:4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

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Chemical Property of 4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

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Technology Process of 4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

There total 5 articles about 4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1573056-14-0
4-(4-aminomethyl-2-methylphenoxy)pyridine-2-carboxylic acid methylamide

: 1553950-73-4
3-amino-1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one

: 7693-46-1
4-Nitrophenyl chloroformate

: 1573056-21-9
4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

Guidance literature:: 3-amino-1-methyl-5-(trifluoromethyl)pyridin-2(1H)-one; 4-Nitrophenyl chloroformate; With pyridine; In dichloromethane; at 20 ℃; for 2h;

4-(4-aminomethyl-2-methylphenoxy)pyridine-2-carboxylic acid methylamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 220000-87-3
4-chloro-N-methylpicolinamide

: 1573056-21-9
4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 96 h / 130 °C

2.1: nickel; hydrogen; ammonia / methanol / 17.5 h / 20 °C

3.1: pyridine / dichloromethane / 2 h / 20 °C

3.2: 16 h / 20 °C

With pyridine; potassium tert-butylate; ammonia; hydrogen; nickel; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 33252-64-1
3-nitro-5-trifluoromethylpyridin-2-ol

: 1573056-21-9
4-{2-methyl-4-[3-(1-methyl-2-oxo-5-trifluoromethyl-1,2-dihydropyridin-3-yl)-ureidomethyl]phenoxy}pyridine-2-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

2.1: hydrogen; 5%-palladium/activated carbon / methanol; tetrahydrofuran / 39 h / 20 °C / 760.05 Torr

3.1: pyridine / dichloromethane / 2 h / 20 °C

3.2: 16 h / 20 °C

With pyridine; 5%-palladium/activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;