1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

Base Information

Chemical Name:1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one
CAS No.:1311293-77-2
Molecular Formula:C₂₀H₂₂N₂O₂
Molecular Weight:322.407
Hs Code.:

Synonyms:1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

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Chemical Property of 1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

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Technology Process of 1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

There total 2 articles about 1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 383375-86-8
1-hydroxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

: 100-44-7
benzyl chloride

: 1311293-77-2
1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16.25h;
DOI:10.1016/j.tet.2011.03.044

Reference yield:

: 90907-07-6
1-carbamoylmethyl-2,3,3-trimethyl-3H-indolinium chloride

: 1311293-77-2
1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / methanol / 0.5 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 16.25 h / 20 °C

With hydroxylamine hydrochloride; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.03.044

Reference yield: 63.0%

: 1311293-77-2
1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one

: 74-88-4
methyl iodide

: 1311293-80-7
1-benzyloxy-2-methoxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indole

Guidance literature:: 1-benzyloxy-9,9,9a-trimethyl-9,9a-dihydro-1H-imidazo[1,2-a]indol-2(3H)-one; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.044