diethyl 3-trifluoromethoxyphenylmalonate

Base Information

• Chemical Name: diethyl 3-trifluoromethoxyphenylmalonate
• CAS No.: 1176959-79-7
• Molecular Formula: C₁₄H₁₅F₃O₅
• Molecular Weight: 320.265
• Mol file: 1176959-79-7.mol

Synonyms:diethyl 3-trifluoromethoxyphenylmalonate

Chemical Property of diethyl 3-trifluoromethoxyphenylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 3-trifluoromethoxyphenylmalonate

There total 1 articles about diethyl 3-trifluoromethoxyphenylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 1-imidazolecarboxylate (19213-72-0) + ethyl 2-(3-(trifluoromethoxy)phenyl)acetate (825645-04-3) → diethyl 3-trifluoromethoxyphenylmalonate (1176959-79-7)

Guidance literature:

ethyl 2-(3-(trifluoromethoxy)phenyl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

ethyl 1-imidazolecarboxylate; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2011.12.067

Reference yield:

diethyl 3-trifluoromethoxyphenylmalonate (1176959-79-7) → 2-(3-trifluoromethoxyphenyl)malonic acid (1176959-72-0)

Guidance literature:

diethyl 3-trifluoromethoxyphenylmalonate; With water; sodium hydroxide; at 65 ℃; for 0.166667h;

With hydrogenchloride; In water; pH=2; Cooling;

Reference yield:

diethyl 3-trifluoromethoxyphenylmalonate (1176959-79-7) → 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt (1176302-25-2,1263140-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 0.17 h / 65 °C

1.2: pH 2 / cooling with ice

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 - 25 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

With oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

ethyl 1-imidazolecarboxylate

ethyl 2-(3-(trifluoromethoxy)phenyl)acetate

Downstream raw materials:

2-(3-trifluoromethoxyphenyl)malonic acid

8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt

2-[3-(trifluoromethoxy)phenyl]propanedioyl dichloride