8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt

Base Information

• Chemical Name: 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt
• CAS No.: 1176302-25-2
• Molecular Formula: C₁₉H₁₁ClF₃N₃O₃S
• Molecular Weight: 453.829
• Mol file: 1176302-25-2.mol

Synonyms:

Chemical Property of 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt

There total 5 articles about 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloro-N-2-thiazolyl-3-pyridinemethanamine (913482-62-9) + 2-(3-trifluoromethoxyphenyl)malonic acid (1176959-72-0) → 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt (1176302-25-2,1263140-36-8)

Guidance literature:

2-(3-trifluoromethoxyphenyl)malonic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 - 25 ℃; for 0.166667h;

6-chloro-N-2-thiazolyl-3-pyridinemethanamine; With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

2-(3-trifluoromethoxyphenyl)malonic acid (1176959-72-0) → 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt (1176302-25-2,1263140-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 - 25 °C

2: triethylamine / dichloromethane / 0.25 h / 0 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

diethyl 3-trifluoromethoxyphenylmalonate (1176959-79-7) → 8-[(6-chloro-3-pyridinyl)methyl]-7-hydroxy-5-oxo-6-[3-(trifluoromethoxy)phenyl]-5H-thiazolo[3,2-a]pyrimidinium inner salt (1176302-25-2,1263140-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 0.17 h / 65 °C

1.2: pH 2 / cooling with ice

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.17 h / 20 - 25 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

With oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In dichloromethane;

upstream raw materials:

6-chloro-N-2-thiazolyl-3-pyridinemethanamine

2-(3-trifluoromethoxyphenyl)malonic acid

6-chloronicotinylaldehyde

N-[(6-chloro-3-pyridinyl)methylene]-2-thiazolamine