N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

Base Information

Chemical Name:N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride
CAS No.:126485-82-3
Molecular Formula:C₁₂H₁₉IN₂O*2ClH
Molecular Weight:407.122
Hs Code.:

Synonyms:N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

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Chemical Property of N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

Chemical Property:

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Technology Process of N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

There total 5 articles about N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 126485-70-9
N,N-dimethyl-N'-(4-trimethylsilylphenoxyethyl)ethylenediamine

: 126485-82-3
N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

Guidance literature:: With hydrogenchloride; N-chloro-succinimide; sodium iodide; In acetic acid; at 65 ℃; for 1h;
DOI:10.1248/cpb.37.2276

Reference yield:

: 13132-25-7
4-(trimethylsilyl)phenol

: 126485-82-3
N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: NaOC₂H₅ / ethanol / 3 h / Heating

2: 2 N NaOH / 0.5 h

3: 67 percent / Phenyl N-phenylphosphoramidochloridate, triethylamine, / CH₂Cl₂ / Ambient temperature

4: 72 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

5: 75 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; lithium aluminium tetrahydride; sodium ethanolate; triethylamine; Phenyl N-phenylphosphoramidochloridate; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.37.2276

Reference yield:

: 126485-60-7
(4-Trimethylsilanyl-phenoxy)-acetic acid

: 126485-82-3
N'-[2-(4-Iodo-phenoxy)-ethyl]-N,N-dimethyl-ethane-1,2-diamine; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / Phenyl N-phenylphosphoramidochloridate, triethylamine, / CH₂Cl₂ / Ambient temperature

2: 72 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

3: 75 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; N-chloro-succinimide; lithium aluminium tetrahydride; triethylamine; Phenyl N-phenylphosphoramidochloridate; sodium iodide; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1248/cpb.37.2276