tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

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Chemical Name:tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate
CAS No.:1450789-74-8
Molecular Formula:C₃₈H₄₁N₅O₈S
Molecular Weight:727.838
Hs Code.:

Synonyms:tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

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Chemical Property of tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

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Technology Process of tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

There total 7 articles about tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

: 1450789-93-1
C₁₂H₁₆N₂O₃S*ClH

: 1450789-74-8
tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 45 ℃; for 4h; pH=> 10;
DOI:10.1021/ml400217r

Reference yield:

: 111331-82-9
3-[(tert-butoxycarbonyl)amino]benzoic acid

: 1450789-74-8
tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 45 °C / pH > 10

With hydrogenchloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/ml400217r

Reference yield:

: 4319-72-6
4-chloro-6-methoxy-2-phenylpyrimidine

: 1450789-74-8
tert-butyl (1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-((pent-4-en-1-ylsulfonyl)carbamoyl)phenyl)amino)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / dimethyl sulfoxide / 48 h / 64 °C / Inert atmosphere; Sealed tube

2: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; potassium carbonate / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 45 °C / pH > 10

With potassium tert-butylate; palladium diacetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/ml400217r