2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

Base Information

Chemical Name:2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid
CAS No.:1450789-66-8
Molecular Formula:C₂₆H₂₇N₃O₆
Molecular Weight:477.517
Hs Code.:

Synonyms:2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

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Chemical Property of 2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

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Technology Process of 2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

There total 3 articles about 2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 95010-17-6
2,4,6-trivinylcycloboroxane pyridine complex

: 1450789-65-7
(S)-2-(3-bromo-4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)phenyl)-2-((tertbutoxycarbonyl)amino)acetic acid

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

Guidance literature:: With palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/ml400217r

Reference yield:

: 4319-72-6
4-chloro-6-methoxy-2-phenylpyrimidine

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 48 h / 64 °C / Inert atmosphere; Sealed tube

2: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; potassium carbonate / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation

With potassium tert-butylate; palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,2-dimethoxyethane; water; dimethyl sulfoxide;
DOI:10.1021/ml400217r

Reference yield:

: 3740-92-9
fenclorim

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / Reflux

2: potassium tert-butylate / dimethyl sulfoxide / 48 h / 64 °C / Inert atmosphere; Sealed tube

3: palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; potassium carbonate / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / Microwave irradiation

With potassium tert-butylate; palladium diacetate; potassium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In methanol; 1,2-dimethoxyethane; water; dimethyl sulfoxide;
DOI:10.1021/ml400217r