[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

Base Information

Chemical Name:[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime
CAS No.:915411-31-3
Molecular Formula:C₃₇H₄₃N₃O₃Si
Molecular Weight:605.852
Hs Code.:

Synonyms:[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

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Chemical Property of [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

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Technology Process of [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

There total 8 articles about [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915411-28-8
(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

: 915411-31-3
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

Guidance literature:: With hydroxylamine hydrochloride; In ethanol; for 2h; Heating / reflux;

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 915411-31-3
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 90 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C

2.2: 0 - 20 °C

3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 24 h / Heating / reflux

4.1: hydroxylamine hydrochloride / ethanol / 2 h / Heating / reflux

With potassium phosphate; hydroxylamine hydrochloride; potassium acetate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; 3.1: Suzuki Coupling;

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915411-31-3
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-pyridin-3-yl-methanone oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 24 h / Heating / reflux

3.1: hydroxylamine hydrochloride / ethanol / 2 h / Heating / reflux

With potassium phosphate; n-butyllithium; hydroxylamine hydrochloride; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In 1,4-dioxane; diethyl ether; ethanol; hexane; water; 2.1: Suzuki Coupling;