(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

Base Information

Chemical Name:(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone
CAS No.:915411-28-8
Molecular Formula:C₃₇H₄₂N₂O₃Si
Molecular Weight:590.838
Hs Code.:

Synonyms:(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

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Chemical Property of (3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

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Technology Process of (3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

There total 8 articles about (3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: 915411-29-9
(3-bromo-5-(4-methoxybenzyloxy)phenyl)(pyridin-3-yl)methanone

: 915411-28-8
(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; water; at 100 ℃; Inert atmosphere;
DOI:10.1021/jm100659v

Reference yield:

: 6311-60-0
3,5-dibromonitrobenzene

: 915411-28-8
(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -75 - -71 °C

2.2: 2 h / -75 - -70 °C

2.3: 0.33 h / -25 - 20 °C

3.1: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; tetrabutylammomium bromide; oxygen; potassium hydroxide; In 1,4-dioxane; diethyl ether; hexane; water; tetramethylurea; 3.1: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915411-28-8
(3-(4-methoxybenzyloxy)-5-(1-(triisopropylsilyl)-1H-indol-4-yl)phenyl)(pyridin-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -75 - -71 °C

1.2: 2 h / -75 - -70 °C

1.3: 0.33 h / -25 - 20 °C

2.1: potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex / 1,4-dioxane; water / 100 °C / Inert atmosphere

With potassium phosphate; n-butyllithium; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; diethyl ether; hexane; water; 2.1: Suzuki coupling;
DOI:10.1021/jm100659v