6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

Base Information

Chemical Name:6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one
CAS No.:1581692-11-6
Molecular Formula:C₃₅H₃₉N₇O₃
Molecular Weight:605.74
Hs Code.:

6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

Synonyms:6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

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Chemical Property of 6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

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Technology Process of 6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

There total 9 articles about 6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₁N₇O₄

: 1581692-11-6
6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

Guidance literature:: With methanol; potassium carbonate; at 45 ℃;

Reference yield:

: 1581692-34-3
2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzaldehyde

: 1581692-11-6
6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

3: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

4: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / Inert atmosphere; Heating

5: potassium carbonate; methanol / 45 °C

With methanol; dmap; sodium tetrahydroborate; potassium phosphate; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; methanol; dichloromethane; water; butan-1-ol;

Reference yield:

: 1581692-35-4
acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

: 1581692-11-6
6-tert-butyl-2-{2-hydroxymethyl-3-[1-methyl-5-(1'-methyl-1',2',3',4',5',6'-hexahydro[3,4']bipyridinyl-6-ylamino)-6-oxo-1,6-dihydropyridazin-3-yl]phenyl}-2H-phthalazin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; palladium diacetate; XPhos / 2-methyltetrahydrofuran / 11 h / Inert atmosphere; Heating

2: XPhos; potassium phosphate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / butan-1-ol; water / Inert atmosphere; Heating

3: potassium carbonate; methanol / 45 °C

With methanol; potassium phosphate; potassium acetate; palladium diacetate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; water; butan-1-ol;