acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

Base Information

Chemical Name:acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester
CAS No.:1581692-35-4
Molecular Formula:C₂₁H₂₁ClN₂O₃
Molecular Weight:384.862
Hs Code.:

Synonyms:acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

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Chemical Property of acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

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Technology Process of acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

There total 6 articles about acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1385022-16-1
6-tert-butyl-2-(3-chloro-2-hydroxymethylphenyl)-2H-phthalazin-1-one

: 108-24-7
acetic anhydride

: 1581692-35-4
acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1581692-34-3
2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzaldehyde

: 1581692-35-4
acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C

With dmap; sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1710-98-1
p-tert-butyl benzoyl chloride

: 1581692-35-4
acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 0 - 25 °C

2.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 - -15 °C / Inert atmosphere

2.2: -78 - 0 °C

3.1: hydrazine hydrate; acetic acid / 1 h / 90 °C

4.1: potassium carbonate; tetraethylammonium chloride / N,N-dimethyl acetamide / 73 h / Inert atmosphere; Heating

5.1: sodium tetrahydroborate / dichloromethane; methanol / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; dmap / dichloromethane / 20 °C

With dmap; sodium tetrahydroborate; tetraethylammonium chloride; sec.-butyllithium; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; cyclohexane;