6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Name:6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1221501-42-3
Molecular Formula:C₂₃H₂₄FN₃O₃
Molecular Weight:409.46
Hs Code.:

Synonyms:6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 8 articles about 6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221501-34-3
6-[5-(4-fluorophenyl)-3-methyl-1-(3-oxobutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

: 75-16-1
methylmagnesium bromide

: 1221501-42-3
6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: 6-[5-(4-fluorophenyl)-3-methyl-1-(3-oxobutyl)-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;

With water; In tetrahydrofuran; diethyl ether; Cooling with ice;

Reference yield:

: 1221503-47-4
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-ol

: 1221501-42-3
6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / toluene / 20 °C / Cooling with ice

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / Reflux; Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 1 h / 20 °C

3.2: Cooling with ice

With caesium carbonate; Dess-Martin periodane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; diethyl ether; water; toluene;

Reference yield:

: 1221503-46-3
4-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]butan-2-one

: 1221501-42-3
6-[5-(4-Fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-3-methyl-1H-pyrazol-4-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 1 h / 20 °C

2.2: Cooling with ice

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; diethyl ether; water;