2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

Base Information

Chemical Name:2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester
CAS No.:171671-39-9
Molecular Formula:C₂₂H₂₇O₆P
Molecular Weight:418.427
Hs Code.:

Synonyms:2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

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Chemical Property of 2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

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Technology Process of 2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

There total 5 articles about 2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 170216-63-4
3-Dibenzyloxooxophosphorio-2-<4-(2',2'-dimethyl-1',3'-dioxolane)>propionic acid methyl ester

: (Z)-3-(Bis-benzyloxy-phosphoryl)-2-hydroxymethyl-acrylic acid methyl ester

: 171671-39-9
2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

Guidance literature:: With methyllithium; In diethyl ether; at -50 ℃; for 0.0833333h;
DOI:10.7164/antibiotics.48.1134

Reference yield: 12.0%

: 917-54-4
methyllithium

: 170216-63-4
3-Dibenzyloxooxophosphorio-2-<4-(2',2'-dimethyl-1',3'-dioxolane)>propionic acid methyl ester

: (Z)-3-(Bis-benzyloxy-phosphoryl)-2-hydroxymethyl-acrylic acid methyl ester

: 171671-39-9
2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

Guidance literature:: In diethyl ether; at -50 ℃; for 0.0833333h;
DOI:10.7164/antibiotics.48.1134

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 171671-39-9
2-<4-(2',2'-Dimethyl-1',3'-dioxolane)>-3-oxobutylphosphonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 5 min, 2.) 0 deg C, 2 h; r.t., 12 h

2: 92 percent / OsO₄, N-methylmorpholine N-oxide / dioxane / 19 h / Ambient temperature

3: 84 percent / p-TsOH / Ambient temperature

4: 18 percent / diethyl ether / 0.08 h / -50 °C

With osmium(VIII) oxide; sodium hydride; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.7164/antibiotics.48.1134