2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

Base Information

Chemical Name:2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide
CAS No.:1441255-95-3
Molecular Formula:C₂₆H₃₇N₅O
Molecular Weight:435.613
Hs Code.:

Synonyms:2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

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Chemical Property of 2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

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Technology Process of 2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

There total 6 articles about 2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2439-56-7
N-methylcyclopentylamine

: 1441257-46-0
2-{4-[1-(2-chloro-pyrimidin-4-yl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide

: 1441255-95-3
2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 - 120 ℃; for 2h; Microwave irradiation;

Reference yield:

: 34645-72-2
(RS)-2-(4'-iodophenyl)propanoic acid

: 1441255-95-3
2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 h / 0 - 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / methanol; 1,4-dioxane / 48 h / Inert atmosphere; Reflux

3: hydrogen; platinum(IV) oxide / ethanol / 6 h / 20 °C / 3750.38 Torr

4: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 100 - 120 °C / Microwave irradiation

With platinum(IV) oxide; 1-hydroxy-7-aza-benzotriazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 41073-25-0
2-(4-iodo-phenyl)-propionic acid methyl ester

: 1441255-95-3
2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 20 h / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / methanol; 1,4-dioxane / 48 h / Inert atmosphere; Reflux

4: hydrogen; platinum(IV) oxide / ethanol / 6 h / 20 °C / 3750.38 Torr

5: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 100 - 120 °C / Microwave irradiation

With platinum(IV) oxide; 1-hydroxy-7-aza-benzotriazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;