(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

Base Information

Chemical Name:(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole
CAS No.:200344-27-0
Molecular Formula:C₂₅H₃₀N₂O₆S
Molecular Weight:486.589
Hs Code.:

Synonyms:(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

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Chemical Property of (5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

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Technology Process of (5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

There total 9 articles about (5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 622-30-0
N-benzyl hydroxylalmine

: 200344-23-6
N-Allyl-N-((3aR,5S,6S,6aR)-5-formyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl)-4-methyl-benzenesulfonamide

: 200344-27-0
(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

Guidance literature:: With 3 A molecular sieve; In benzene; at 25 ℃; for 16h;
DOI:10.1016/S0040-4020(99)00694-8

Reference yield: 78.0%

: C₂₅H₃₀N₂O₆S

: 200344-27-0
(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

Guidance literature:: DOI:10.1016/S0040-4039(97)10287-8

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 200344-27-0
(5aS,6R,7R,8aR)-1-benzyl-5-p-toluenesulphonyl-1,3,3a,5a,6,7,8a,8b-octahydro-6,7-isopropylidenedioxy-4H-furo[2',3':5,6]pyrido[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 16 h / 25 °C

2: K₂CO₃ / acetone / 24 h / 25 °C

3: 90 percent / aq. acetic acid / 14 h / 20 °C

4: NaIO₄ / aq. methanol / 2 h / 25 °C

5: 78 percent / 3A molecular sieves / benzene / 16 h / 25 °C

With pyridine; sodium periodate; 3 A molecular sieve; potassium carbonate; acetic acid; In methanol; acetone; benzene; 1: Tosylation / 2: Alkylation / 3: Hydrolysis / 4: Oxidation / 5: Condensation;
DOI:10.1016/S0040-4020(99)00694-8