(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:675848-79-0
Molecular Formula:C₄₆H₄₀N₆O₈
Molecular Weight:804.859
Hs Code.:

Synonyms:(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

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Chemical Property of (1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

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Technology Process of (1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

There total 13 articles about (1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 675848-79-0
(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / Heating

1.2: 90 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 3 h / Heating

2.1: 90 percent / LiOH / tetrahydrofuran; H₂O / 0.75 h / 20 °C

3.1: 91 percent / dimethylformamide / 4 h / 100 °C

4.1: 452 mg / pyridine

With pyridine; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Vorbrueggen coupling;
DOI:10.1016/j.bmc.2004.02.008

Reference yield:

: 293751-03-8
1,2-di-O-acetyl-3-O-benzyl-4-C-methanesulfonyloxymethyl-5-O-methanesulfonyl-D-erythro-pentofuranose

: 675848-79-0
(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / Heating

1.2: 90 percent / trimethylsilyl triflate / 1,2-dichloro-ethane / 3 h / Heating

2.1: 90 percent / LiOH / tetrahydrofuran; H₂O / 0.75 h / 20 °C

3.1: 91 percent / dimethylformamide / 4 h / 100 °C

4.1: 452 mg / pyridine

With pyridine; lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Vorbrueggen coupling;
DOI:10.1016/j.bmc.2004.02.008

Reference yield:

: 675848-74-5
(1S,3R,4R,7S)-3-(2-amino-6-chloropurin-9-yl)-7-benzyloxy-1-methanesulfonyloxymethyl-2,5-dioxabicyclo[2.2.1]heptane

: 675848-79-0
(1R,3R,4R,7S)-3-(2,6-di(N-benzoylamino)purin-9-yl)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / dimethylformamide / 4 h / 100 °C

2: 452 mg / pyridine

With pyridine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.02.008