2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2,2-difluoro-2-(3-methoxyphenyl)acetic acid
CAS No.:1027513-99-0
Molecular Formula:C₉H₈F₂O₃
Molecular Weight:202.158
Hs Code.:

Synonyms:2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Suppliers and Price of 2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,2-difluoro-2-(3-methoxyphenyl)acetic acid

There total 5 articles about 2,2-difluoro-2-(3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1027513-99-0
2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 55.0%

: 915133-57-2
2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester

: 1027513-99-0
2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Guidance literature:: With potassium carbonate; In methanol; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield: 43.0%

: 766-85-8
3-methoxy-1-iodobenzene

: 667-27-6
Ethyl bromodifluoroacetate

: 1027513-99-0
2,2-difluoro-2-(3-methoxyphenyl)acetic acid

Guidance literature:: 3-methoxy-1-iodobenzene; Ethyl bromodifluoroacetate; With copper; In dimethyl sulfoxide; at 60 ℃; for 12h;

With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/acs.orglett.6b01188