915133-57-2

Basic information

• Product Name: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester
• Synonyms: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester
• CAS NO: 915133-57-2
• Molecular Weight: 230.211
• Mol File: 915133-57-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester(915133-57-2)
• EPA Substance Registry System: 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester(915133-57-2)

Safety Data

• Hazardous Substances Data: 915133-57-2(Hazardous Substances Data)

Usage

General Description

2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester is a chemical compound which is commonly used as a reactant in organic synthesis. 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester is an ethyl ester derivative of 2,2-difluoro-2-(3-methoxyphenyl)acetic acid, and it is characterized by the presence of a difluoromethyl group and a methoxyphenyl group. It is known for its potential applications in pharmaceutical and agrochemical industries, and it is often used as an intermediate in the synthesis of various compounds. Additionally, 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester is also used as a building block in the production of diverse drugs and active pharmaceutical ingredients.

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 66107-33-3 3-methoxyphenyl triflate 
• 100-66-3 methoxybenzene 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 766-85-8 3-methoxy-1-iodobenzene 

Downstream Products

• 1027513-99-0 2,2-difluoro-2-(3-methoxyphenyl)acetic acid 
• 454-90-0 3-(trifluoromethyl)anisole 
• 1393726-84-5 5-[2,2-difluoro-2-(3-methoxyphenyl)ethyl]-1,3,5-dioxazinane 
• 1393726-83-4 1,3,5-tris[2,2-difluoro-2-(3-methoxyphenyl)ethyl]-1,3,5-triazinane 
• 1393560-28-5 2,2-difluoro-2-(3-methoxyphenyl)ethylamine 
• 1393726-82-3 2,2-difluoro-2-(3-methoxyphenyl)acetamide 

Relevant articles and documents

Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenyl ethan-1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.

Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides

A palladium-catalyzed Negishi cross-coupling reaction of ethyl bromodifluoroacetate with aryl bromides or aryl triflates to construct C(sp2)-CF2 bonds is described. The reaction was conducted under mild reaction conditions, and no preparation of organozinc reagents is required. This is the first report encompassing the conversion of aryl triflates into products containing C-CF2 bonds. In addition, the construction of C(sp2)-CHF bonds was achieved under mild conditions via a cross-coupling of aryl iodides with ethyl bromofluoroacetate.

Silver-Mediated C–H Difluoromethylation of Arenes

The first AgI-mediated C–H ethoxycarbonyl difluoromethylation with TMSCF2COOEt (TMS = trimethylsilyl) has been developed. The radical difluoromethylation proceeds smoothly to give the difluoromethylated arenes in moderate to high yie