2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

Base Information

Chemical Name:2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide
CAS No.:1269494-67-8
Molecular Formula:C₂₅H₁₆N₄OS
Molecular Weight:420.494
Hs Code.:

Synonyms:2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

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Chemical Property of 2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

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Technology Process of 2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

There total 4 articles about 2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7357-70-2
Cyanothioacetamide

: 946853-80-1
3-naphtho[2,1-b]furan-2-yl-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1269494-67-8
2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

Guidance literature:: With piperidine; for 3h; Reflux;
DOI:10.3390/molecules16010307

Reference yield:

: 49841-22-7
1-(naphtho[2,1-b]furan-2-yl)ethan-1-one

: 1269494-67-8
2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / Reflux

2.1: trichlorophosphate / 1.25 h / 0 °C

2.2: 0 - 90 °C

3.1: piperidine / 3 h / Reflux

With piperidine; trichlorophosphate; In ethanol; 2.1: Vilsmeier formylation / 2.2: Vilsmeier formylation;
DOI:10.3390/molecules16010307

Reference yield:

: 708-06-5
2-hydroxynaphthalene-1-carbaldehyde

: 1269494-67-8
2-cyano-3-(3-(naphtho[2,1-b]furan-2-yl)-1-phenyl-1H-pyrazol-4-yl) prop-2-enethioamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 8 h / Reflux

2.1: ethanol / 2 h / Reflux

3.1: trichlorophosphate / 1.25 h / 0 °C

3.2: 0 - 90 °C

4.1: piperidine / 3 h / Reflux

With piperidine; potassium carbonate; trichlorophosphate; In ethanol; acetone; 3.1: Vilsmeier formylation / 3.2: Vilsmeier formylation;
DOI:10.3390/molecules16010307