diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Base Information

Chemical Name:diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate
CAS No.:1441049-06-4
Molecular Formula:C₂₂H₁₈F₆N₂O₄
Molecular Weight:488.386
Hs Code.:

Synonyms:diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

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Technology Process of diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

There total 2 articles about diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2445-85-4
ethyl 2-((4-(trifluoromethyl)phenyl)amino)acetate

: 1441049-06-4
diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Guidance literature:: With iron(II) triflate; 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube; Inert atmosphere;
DOI:10.1021/jo4007199

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 1441049-06-4
diethyl 6-(trifluoromethyl)-3-(4-(trifluoromethyl)phenyl)-3,4-dihydroquinazoline-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / ethanol / 85 - 90 °C

2: 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; iron(II) triflate / 1,2-dichloro-ethane / 24 h / 60 °C / Sealed tube; Inert atmosphere

With iron(II) triflate; sodium acetate; 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jo4007199