((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

Base Information

Chemical Name:((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester
CAS No.:1003309-14-5
Molecular Formula:C₁₈H₁₆BrNO₃
Molecular Weight:374.234
Hs Code.:

Synonyms:((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

Suppliers and Price of ((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

There total 1 articles about ((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 131770-56-4
2-(4-bromophenylamino)acetic acid methyl ester

: 1003309-14-5
((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

Guidance literature:: With pyridine; dmap; at 20 ℃; for 2h;

Reference yield: 97.0%

: 1003309-14-5
((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

: 1003309-15-6
{(4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino}acetic acid

Guidance literature:: ((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester; With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 0.75h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 1003309-14-5
((4-bromophenyl)-[(E)-(3-phenylacryloyl)]amino)acetic acid methyl ester

: (E)-N-[2-((S)-3-aminopyrrolidin-1-yl)-2-oxo-ethyl]-N-(4-phenoxyphenyl)-3-phenylacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; lithium hydroxide; water / tetrahydrofuran / 0.75 h / 20 °C

2.1: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: potassium acetate / palladium diacetate / N,N-dimethyl-formamide / 5.5 h / 85 °C

4.1: sodium periodate; ammonium acetate / acetone / 64 h / 20 °C

4.2: 4 h

4.3: pH 1

5.1: triethylamine / copper diacetate / dichloromethane / 16 h / 20 °C / Molecular sieve

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With 4-methyl-morpholine; methanol; lithium hydroxide; sodium periodate; 1-hydroxy-7-aza-benzotriazole; ammonium acetate; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium diacetate; copper diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;