cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester

Base Information

• Chemical Name: cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester
• CAS No.: 852044-44-1
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 852044-44-1.mol

Synonyms:cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester

Chemical Property of cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester

There total 3 articles about cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl chloroformate (79-22-1) + N-(Cyclohex-2-enyl)-4-methoxybenzylamine (250261-56-4) → cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester (852044-44-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/ol035873n

Reference yield:

4-methoxy-benzylamine (2393-23-9) → cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester (852044-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / potassium carbonate / acetonitrile / 16 h / 20 °C

2: 89 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ol035873n

Reference yield:

rac-3-bromocyclohexene (1521-51-3,113667-32-6) → cyclohex-2-enyl-(4-methoxy-benzyl)-carbamic acid methyl ester (852044-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / potassium carbonate / acetonitrile / 16 h / 20 °C

2: 89 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / 20 °C

With dmap; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/ol035873n

upstream raw materials:

methyl chloroformate

N-(Cyclohex-2-enyl)-4-methoxybenzylamine

4-methoxy-benzylamine

rac-3-bromocyclohexene