1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Base Information

Chemical Name:1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>
CAS No.:137016-63-8
Molecular Formula:C₃₂H₃₆Cl₄N₃O₉PSi
Molecular Weight:807.524
Hs Code.:

Synonyms:1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

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Chemical Property of 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

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Technology Process of 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

There total 9 articles about 1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 137016-62-7
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

: 137016-63-8
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.166667h; Ambient temperature;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6478-73-5
5,6-dichlorobenzimidazole

: 137016-63-8
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Guidance literature:: Multi-step reaction with 6 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 82 percent / p-TsOH / CH₂Cl₂; methanol / 0.17 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 137016-63-8
1-(3-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Guidance literature:: Multi-step reaction with 6 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 82 percent / p-TsOH / CH₂Cl₂; methanol / 0.17 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol; dichloromethane;
DOI:10.1016/0008-6215(92)84178-U