methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide

Base Information

• Chemical Name: methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide
• CAS No.: 273754-89-5
• Molecular Formula: C₁₀H₁₄S
• Molecular Weight: 170.255
• Mol file: 273754-89-5.mol

Synonyms:methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide

Chemical Property of methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide

There total 5 articles about methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2,3,3-tetradeuterio-3-phenylpropyl p-toluenesulfonate (273754-88-4) + sodium thiomethoxide (5188-07-8) → methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide (273754-89-5)

Guidance literature:

In tetrahydrofuran; ethanol; for 3h;

DOI:10.1021/ja994150p

Reference yield: 98.0%

sodium thiomethanolate + 2,2,3,3-tetradeuterio-3-phenylpropyl p-toluenesulfonate (273754-88-4) → methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide (273754-89-5)

Guidance literature:

In tetrahydrofuran; ethanol; for 3h;

DOI:10.1021/jo0160625

Reference yield:

phenylpropynoic acid ethyl ester (2216-94-6) → methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfide (273754-89-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / D₂ / Pd/C / diethyl ether

2: 98 percent / LiAlH₄ / tetrahydrofuran / 6 h / from 0 deg C to reflux

3: 71 percent / pyridine / CHCl₃ / 2.5 h

4: 100 percent / ethanol; tetrahydrofuran / 3 h

With pyridine; lithium aluminium tetrahydride; deuterium; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; chloroform; 1: Catalytic hydrogenation / 2: Reduction / 3: Tosylation / 4: Substitution;

DOI:10.1021/ja994150p

upstream raw materials:

2,2,3,3-tetradeuterio-3-phenylpropyl p-toluenesulfonate

sodium thiomethoxide

2,2,3,3-tetradeuterio-3-phenyl-1-propanol

ethyl 3-(4-fluorophenyl)propanoate-α,β-d₄

Downstream raw materials:

methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfone

Refernces

• 1、 Cubbage, Jerry W.,Vos, Brian W.,Jenks, William S.. "Ei elimination: An unprecedented facet of sulfone chemistry". . p. 4968 - 4971. Retrieved 2007/10/03.