Technology Process of methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfone
There total 5 articles about methyl 2,2,3,3-tetradeuterio-3-phenylpropyl sulfone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
for 3h;
DOI:10.1021/ja994150p
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / D2 / Pd/C / diethyl ether
2: 98 percent / LiAlH4 / tetrahydrofuran / 6 h / from 0 deg C to reflux
3: 71 percent / pyridine / CHCl3 / 2.5 h
4: 100 percent / ethanol; tetrahydrofuran / 3 h
5: 100 percent / m-chloroperbenzoic acid / CH2Cl2 / 3 h
With
pyridine; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; deuterium;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform;
1: Catalytic hydrogenation / 2: Reduction / 3: Tosylation / 4: Substitution / 5: Oxidation;
DOI:10.1021/ja994150p
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / LiAlH4 / tetrahydrofuran / 6 h / from 0 deg C to reflux
2: 71 percent / pyridine / CHCl3 / 2.5 h
3: 100 percent / ethanol; tetrahydrofuran / 3 h
4: 100 percent / m-chloroperbenzoic acid / CH2Cl2 / 3 h
With
pyridine; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform;
1: Reduction / 2: Tosylation / 3: Substitution / 4: Oxidation;
DOI:10.1021/ja994150p
