toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester
• CAS No.: 1095280-67-3
• Molecular Formula: C₁₈H₂₁NO₅S
• Molecular Weight: 363.434
• Mol file: 1095280-67-3.mol

Synonyms:toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester

Chemical Property of toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester

There total 1 articles about toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

tert-butyl N-hydroxy-N-phenylcarbamate (58377-40-5) + p-toluenesulfonyl chloride (98-59-9) → toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester (1095280-67-3)

Guidance literature:

With triethylamine; In chloroform; at 0 - 20 ℃;

DOI:10.1055/s-0030-1258546

Reference yield: 89.0%

toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester (1095280-67-3) → 2-aminophenyl p-toluenesulfonate (1216-96-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1002/ejoc.200800672

Reference yield:

1-Heptyne (628-71-7) + toluene-4-sulfonic acid 2-tert-butoxycarbonylaminophenyl ester (1095280-67-3) → C18H25NO2

Guidance literature:

With potassium phosphate; palladium(II) trifluoroacetate; 1-dicyclohexylphosphino-2-(di-tert-butylphosphinoethyl)ferrocene; In tert-butyl alcohol; at 85 ℃; for 18h; Inert atmosphere;

DOI:10.1002/chem.201001524

upstream raw materials:

tert-butyl N-hydroxy-N-phenylcarbamate

p-toluenesulfonyl chloride

Downstream raw materials:

2-aminophenyl p-toluenesulfonate

1,1-dimethylethyl N-[2-(phenylethynyl)phenyl]carbamate