2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide

Base Information

• Chemical Name: 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide
• CAS No.: 1190970-38-7
• Molecular Formula: C₂₅H₃₀ClF₂N₃O₄S₂
• Molecular Weight: 574.113
• Mol file: 1190970-38-7.mol

Synonyms:2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide

Chemical Property of 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide

There total 4 articles about 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid (1186240-93-6) + 2-((3,3-difluoroazetidin-1-yl)methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (1192731-64-8) → 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide (1190970-38-7)

Guidance literature:

2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid; With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; at 20 ℃; for 0.5h;

2-((3,3-difluoroazetidin-1-yl)methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate (1190971-05-1) → 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide (1190970-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.1: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

2-chloro-N-cyclopropyl-N-(2-hydroxyethyl)-6-methyl-benzenesulfonamide (1190971-04-0) → 2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide (1190970-38-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.1: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.5 h / 20 °C

3.2: 20 °C

With tetrabutyl-ammonium chloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid

2-((3,3-difluoroazetidin-1-yl)methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride

2-chloro-N-cyclopropyl-N-(2-hydroxyethyl)-6-methyl-benzenesulfonamide

tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate