tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate

Base Information

• Chemical Name: tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate
• CAS No.: 1190971-05-1
• Molecular Formula: C₁₈H₂₆ClNO₅S
• Molecular Weight: 403.927
• Mol file: 1190971-05-1.mol

Synonyms:tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate

Chemical Property of tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate

There total 3 articles about tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2-chloro-N-cyclopropyl-N-(2-hydroxyethyl)-6-methyl-benzenesulfonamide (1190971-04-0) → tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate (1190971-05-1)

Guidance literature:

With tetrabutyl-ammonium chloride; sodium hydroxide; In dichloromethane; water; at 0 - 20 ℃;

Reference yield:

2-(cyclopropylamino)ethan-1-ol (35265-06-6) → tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate (1190971-05-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 0 - 25 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane / 0 - 20 °C

With tetrabutyl-ammonium chloride; triethylamine; sodium hydroxide; In dichloromethane;

Reference yield:

→ tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methyl-phenylsulfonylamino)ethoxy)acetate (1190971-05-1)

Guidance literature:

upstream raw materials:

bromoacetic acid tert-butyl ester

2-chloro-N-cyclopropyl-N-(2-hydroxyethyl)-6-methyl-benzenesulfonamide

2-(cyclopropylamino)ethan-1-ol

Downstream raw materials:

2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetic acid

N-[2-[2-[2-(azetidin-1-yl-methyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-2-chloro-N-cyclopropyl-6-methyl-benzenesulfonic acid amide

2-chloro-N-cyclopropyl-N-[2-[2-[2-[(3,3-difluoro-azetidin-1-yl)-methyl]-4,5,6,7-tetrahydro-thieno[3,2-c]pyridin-5-yl]-2-oxo-ethoxy]-ethyl]-6-methyl-benzenesulfonic acid amide