[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

Base Information

Chemical Name:[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone
CAS No.:1189175-81-2
Molecular Formula:C₁₉H₂₂ClF₂NO₂Si
Molecular Weight:397.924
Hs Code.:

Synonyms:[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

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Chemical Property of [5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

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Technology Process of [5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

There total 3 articles about [5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189175-80-1
4-chloro-3,5-difluoro-N-methoxy-N-methylbenzamide

: 145733-53-5
2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine

: 1189175-81-2
[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

Guidance literature:: 2-bromo-5-(tert-butyldimethylsilyloxy methyl)-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

4-chloro-3,5-difluoro-N-methoxy-N-methylbenzamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h;

Reference yield:

: 122306-01-8
2-bromo-5-(hydroxymethyl)pyridine

: 1189175-81-2
[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1189175-81-2
[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl](4-chloro-3,5-difluorophenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 - 20 °C

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;