6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

Base Information

Chemical Name:6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine
CAS No.:959839-58-8
Molecular Formula:C₂₄H₃₀FN₇O₂
Molecular Weight:467.546
Hs Code.:

6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

Synonyms:6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

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Chemical Property of 6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

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Technology Process of 6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

There total 4 articles about 6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959841-72-6
N,N-Dimethyl-2-(5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl)propan-2-amine

: 959841-64-6
5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic acid

: 959839-58-8
6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

Guidance literature:: 5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

N,N-Dimethyl-2-(5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl)propan-2-amine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 959841-71-5
Benzyl 3-[1-(dimethylamino)-1-methylethyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

: 959839-58-8
6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 1 h / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 959841-63-5
5-[(4,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)methyl]-2-fluorobenzonitrile

: 959839-58-8
6-(3-(3-(1-(dimethylamino-1-methylethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)carbonyl)-4-fluorobenzyl)-4,5-dimethyl-3-oxo-2,3-dihydro-pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / 1 h / 100 °C

1.2: 0 °C / pH 2 - 3

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 1 h / 20 °C

With sodium hydroxide; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;