3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

Base Information

Chemical Name:3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]
CAS No.:310890-30-3
Molecular Formula:C₄₇H₅₇N₃O₉
Molecular Weight:807.984
Hs Code.:

3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

Synonyms:3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

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Chemical Property of 3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

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Technology Process of 3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

There total 10 articles about 3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: D-phenylalanine N-methylamide trifluoroacetate

: 310890-26-7
5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

: 310890-30-3
3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; for 15h;
DOI:10.1016/S0040-4020(00)00687-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 310890-30-3
3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

2.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 70 percent / Me₂S / CH₂Cl₂ / -78 - 0 °C

3.1: 94 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h

4.1: 93 percent / EDC; HOBT; N-methylmorpholine / tetrahydrofuran / 15 h

With 4-methyl-morpholine; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1.1: Condensation / 2.1: ozonolysis / 2.2: Reduction / 3.1: Oxidation / 4.1: Condensation;
DOI:10.1016/S0040-4020(00)00687-6

Reference yield:

: 31938-11-1
O-tritylhydroxylamine

: 310890-30-3
3(S)-isobutyl-5(S)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S),4(R)-dicarboxylic acid 2-(tert-butoxycarbonyl-trityloxy-amide) 4-[(1-methylcarbamoyl-2(R)-phenyl-ethyl)amide]

Guidance literature:: Multi-step reaction with 5 steps

1.1: 66 percent / EDC; HOBT; N-methylmorpholine / tetrahydrofuran

2.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

3.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

3.2: 70 percent / Me₂S / CH₂Cl₂ / -78 - 0 °C

4.1: 94 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h

5.1: 93 percent / EDC; HOBT; N-methylmorpholine / tetrahydrofuran / 15 h

With 4-methyl-morpholine; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1.1: Condensation / 2.1: Condensation / 3.1: ozonolysis / 3.2: Reduction / 4.1: Oxidation / 5.1: Condensation;
DOI:10.1016/S0040-4020(00)00687-6