5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

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Chemical Name:5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid
CAS No.:310890-26-7
Molecular Formula:C₃₇H₄₅NO₉
Molecular Weight:647.766
Hs Code.:

Synonyms:5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

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Chemical Property of 5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

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Technology Process of 5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

There total 9 articles about 5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 310890-22-3
4(R)-formyl-3(S)-isobutyl-5(R)-(2-methoxy-ethoxy)-tetrahydro-furan-2(S)-carboxylic acid, tert-butoxycarbonyl-trityloxy-amide

: 310890-26-7
5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; for 3h;
DOI:10.1016/S0040-4020(00)00687-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 310890-26-7
5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

2.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

2.2: 70 percent / Me₂S / CH₂Cl₂ / -78 - 0 °C

3.1: 94 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; ozone; triethylamine; In dichloromethane; water; tert-butyl alcohol; 1.1: Condensation / 2.1: ozonolysis / 2.2: Reduction / 3.1: Oxidation;
DOI:10.1016/S0040-4020(00)00687-6

Reference yield:

: 31938-11-1
O-tritylhydroxylamine

: 310890-26-7
5(S)-(tert-butoxycarbonyl-trityloxy-carbamoyl)-4(S)-isobutyl-2(R)-(2-methoxy-ethoxy)-tetrahydro-furan-3(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 66 percent / EDC; HOBT; N-methylmorpholine / tetrahydrofuran

2.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

3.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

3.2: 70 percent / Me₂S / CH₂Cl₂ / -78 - 0 °C

4.1: 94 percent / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 3 h

With 4-methyl-morpholine; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol; 1.1: Condensation / 2.1: Condensation / 3.1: ozonolysis / 3.2: Reduction / 4.1: Oxidation;
DOI:10.1016/S0040-4020(00)00687-6