1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Base Information

Chemical Name:1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine
CAS No.:1357390-61-4
Molecular Formula:C₂₂H₃₀N₄O₅S₂
Molecular Weight:494.636
Hs Code.:

Synonyms:1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

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Chemical Property of 1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

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Technology Process of 1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

There total 6 articles about 1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1357390-52-3
1-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

: 124-63-0
methanesulfonyl chloride

: 1357390-61-4
1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-95-1
methyl [5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetate

: 1357390-61-4
1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

2: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3: potassium carbonate / acetonitrile / 20 h / Reflux

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 1034.32 Torr

5: triethylamine / dichloromethane / 20 °C

With lithium borohydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-59-7
2-(3-phenoxybenzyl)-1,2,5-thiadiazolidine 1,1-dioxide

: 1357390-61-4
1-methanesulfonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; acetonitrile; mineral oil / 0.25 h

1.2: 20 °C

2.1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 h / Reflux

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 24 h / 1034.32 Torr

6.1: triethylamine / dichloromethane / 20 °C

With lithium borohydride; palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2011.10.019